Ontology highlight
ABSTRACT:
SUBMITTER: Baru AM
PROVIDER: S-EPMC3468440 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Baru Abdul Mannan AM Ganesh Venkateswaran V Krishnaswamy Jayendra Kumar JK Hesse Christina C Untucht Christopher C Glage Silke S Behrens Georg G Mayer Christian Thomas CT Puttur Franz F Sparwasser Tim T
PloS one 20121010 10
Regulatory T cells (Tregs) play a non-redundant role in maintenance of immune homeostasis. This is achieved by suppressing both, priming of naïve cells and effector cell functions. Although Tregs have been implicated in modulating allergic immune responses, their influence on distinct phases of development of allergies remains unclear. In this study, by using bacterial artificial chromosome (BAC)-transgenic Foxp3-DTR (DEREG) mice we demonstrate that the absence of Foxp3(+) Tregs during the aller ...[more]