Ontology highlight
ABSTRACT:
SUBMITTER: Yanez DC
PROVIDER: S-EPMC6396086 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Yánez Diana C DC Sahni Hemant H Ross Susan S Solanki Anisha A Lau Ching-In CI Papaioannou Eleftheria E Barbarulo Alessandro A Powell Rebecca R Lange Ulrike C UC Adams David J DJ Barenco Martino M Ono Masahiro M D'Acquisto Fulvio F Furmanski Anna L AL Crompton Tessa T
European journal of immunology 20181109 1
The interferon-inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4<sup>+</sup> Th cell differentiation. Ifitm2 and Ifitm3 are expressed in wild-type (WT) CD4<sup>+</sup> T cells. On activation, Ifitm3 was downregulated and Ifitm2 was upregulated. Resting Ifitm-family-deficient CD4<sup>+</sup> T cells had higher expression of Th1-associated genes than WT and purified naive Ifitm-family-deficient ...[more]