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Glucose delays age-dependent proteotoxicity.

ABSTRACT: Nutrient availability influences an organism's life history with profound effects on metabolism and lifespan. The association between a healthy lifespan and metabolism is incompletely understood, but a central factor is glucose metabolism. Although glucose is an important cellular energy source, glucose restriction is associated with extended lifespan in simple animals and a reduced incidence of age-dependent pathologies in humans. We report here that glucose enrichment delays mutant polyglutamine, TDP-43, FUS, and amyloid-? toxicity in Caenorhabditis elegans models of neurodegeneration by reducing protein misfolding. Dysregulated metabolism is common to neurodegeneration and we show that glucose enrichment is broadly protective against proteotoxicity.

SUBMITTER: Tauffenberger A

PROVIDER: S-EPMC3470697 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Glucose delays age-dependent proteotoxicity.

Tauffenberger Arnaud A Vaccaro Alexandra A Aulas Anais A Vande Velde Christine C Parker J Alex JA

Aging cell 20120801 5

Nutrient availability influences an organism's life history with profound effects on metabolism and lifespan. The association between a healthy lifespan and metabolism is incompletely understood, but a central factor is glucose metabolism. Although glucose is an important cellular energy source, glucose restriction is associated with extended lifespan in simple animals and a reduced incidence of age-dependent pathologies in humans. We report here that glucose enrichment delays mutant polyglutami ...[more]

PMID: 22734670

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