Ontology highlight
ABSTRACT:
SUBMITTER: Xu W
PROVIDER: S-EPMC3470909 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Xu Wei W Lu Jing-Ping JP Ye Qi-Zhuang QZ
Journal of medicinal chemistry 20120914 18
Natural-product-derived bengamides possess potent antiproliferative activity and target human methionine aminopeptidases (MetAPs) for their cellular effects. Several derivatives were designed, synthesized, and evaluated as MetAP inhibitors. Here, we present four new X-ray structures of human MetAP1 in complex with the inhibitors. Together with the previous structures of bengamide derivatives with human MetAP2 and tubercular MtMetAP1c, analysis of the interactions of these inhibitors at the activ ...[more]