Ontology highlight
ABSTRACT:
SUBMITTER: Weglarz-Tomczak E
PROVIDER: S-EPMC4867306 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Węglarz-Tomczak Ewelina E Berlicki Łukasz Ł Pawełczak Małgorzata M Nocek Bogusław B Joachimiak Andrzej A Mucha Artur A
European journal of medicinal chemistry 20160409
N'-substituted 1,2-diaminoethylphosphonic acids and 1,2-diaminoethylphosphinic dipeptides were explored to unveil the structural context of the unexpected selectivity of these inhibitors of M1 alanine aminopeptidases (APNs) versus M17 leucine aminopeptidase (LAP). The diaminophosphonic acids were obtained via aziridines in an improved synthetic procedure that was further expanded for the phosphinic pseudodipeptide system. The inhibitory activity, measured for three M1 and one M17 metalloaminopep ...[more]