Ontology highlight
ABSTRACT:
SUBMITTER: Kang HS
PROVIDER: S-EPMC3471652 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20120822 20
The extract of UIC 10035, a strain obtained from a sample collected near the town of Homestead, South Florida, showed antiproliferative activity against MDA-MB-435 cells. Bioassay-guided fractionation led to the isolation of a series of cyclic lipodecapeptides, named minutissamides E-L (1-8). The planar structures were determined by analysis of HRESIMS, tandem MS, and 1D and 2D NMR data, and the stereoconfigurations were assigned by LC-MS analysis of the Marfey's derivatives after acid hydrolysi ...[more]