Ontology highlight
ABSTRACT:
SUBMITTER: Iverson TM
PROVIDER: S-EPMC3471735 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Iverson Tina M TM Maklashina Elena E Cecchini Gary G
The Journal of biological chemistry 20120817 42
Complex II couples oxidoreduction of succinate and fumarate at one active site with that of quinol/quinone at a second distinct active site over 40 Å away. This process links the Krebs cycle to oxidative phosphorylation and ATP synthesis. The pathogenic mutation or inhibition of human complex II or its assembly factors is often associated with neurodegeneration or tumor formation in tissues derived from the neural crest. This brief overview of complex II correlates the clinical presentations of ...[more]