Ontology highlight
ABSTRACT:
SUBMITTER: Serna M
PROVIDER: S-EPMC4743022 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Serna Marina M Giles Joanna L JL Morgan B Paul BP Bubeck Doryen D
Nature communications 20160204
In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a 'multi-hit' mechanism; however, sublytic MAC pores on host cells activate signalling pathways. Previous studies have described the structures of individual MAC components and subcomplexes; however, the molecular details of its assembly and mechanism of action remain unresolved. Here we report the electron cryo-microscopy st ...[more]