Ontology highlight
ABSTRACT:
SUBMITTER: Hurd TR
PROVIDER: S-EPMC3471752 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Hurd Thomas R TR Collins Yvonne Y Abakumova Irina I Chouchani Edward T ET Baranowski Bartlomiej B Fearnley Ian M IM Prime Tracy A TA Murphy Michael P MP James Andrew M AM
The Journal of biological chemistry 20120821 42
Reactive oxygen species are byproducts of mitochondrial respiration and thus potential regulators of mitochondrial function. Pyruvate dehydrogenase kinase 2 (PDHK2) inhibits the pyruvate dehydrogenase complex, thereby regulating entry of carbohydrates into the tricarboxylic acid (TCA) cycle. Here we show that PDHK2 activity is inhibited by low levels of hydrogen peroxide (H(2)O(2)) generated by the respiratory chain. This occurs via reversible oxidation of cysteine residues 45 and 392 on PDHK2 a ...[more]