Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC4034658 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Li Qi Q Liu Xue X Yin Yu Y Zheng Ji-Tai JT Jiang Cheng-Fei CF Wang Jing J Shen Hua H Li Chong-Yong CY Wang Min M Liu Ling-Zhi LZ Jiang Bing-Hua BH
Oxidative medicine and cellular longevity 20140508
Although insulin is known to regulate glucose metabolism and closely associate with liver cancer, the molecular mechanisms still remain to be elucidated. In this study, we attempt to understand the mechanism of insulin in promotion of liver cancer metabolism. We found that insulin increased pyruvate kinase M2 (PKM2) expression through reactive oxygen species (ROS) for regulating glucose consumption and lactate production, key process of glycolysis in hepatocellular carcinoma HepG2 and Bel7402 ce ...[more]