Ontology highlight
ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC3471781 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Du Jiamu J Zhong Xuehua X Bernatavichute Yana V YV Stroud Hume H Feng Suhua S Caro Elena E Vashisht Ajay A AA Terragni Jolyon J Chin Hang Gyeong HG Tu Andy A Hetzel Jonathan J Wohlschlegel James A JA Pradhan Sriharsa S Patel Dinshaw J DJ Jacobsen Steven E SE
Cell 20120901 1
DNA methylation and histone modification exert epigenetic control over gene expression. CHG methylation by CHROMOMETHYLASE3 (CMT3) depends on histone H3K9 dimethylation (H3K9me2), but the mechanism underlying this relationship is poorly understood. Here, we report multiple lines of evidence that CMT3 interacts with H3K9me2-containing nucleosomes. CMT3 genome locations nearly perfectly correlated with H3K9me2, and CMT3 stably associated with H3K9me2-containing nucleosomes. Crystal structures of m ...[more]