Ontology highlight
ABSTRACT:
SUBMITTER: Fiumara F
PROVIDER: S-EPMC3472970 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Fiumara Ferdinando F Fioriti Luana L Kandel Eric R ER Hendrickson Wayne A WA
Cell 20101201 7
The functional switch of glutamine/asparagine (Q/N)-rich prions and the neurotoxicity of polyQ-expanded proteins involve complex aggregation-prone structural transitions, commonly presumed to be forming β sheets. By analyzing sequences of interaction partners of these proteins, we discovered a recurrent presence of coiled-coil domains both in the partners and in segments that flank or overlap Q/N-rich and polyQ domains. Since coiled coils can mediate protein interactions and multimerization, we ...[more]