Ontology highlight
ABSTRACT:
SUBMITTER: Seto J
PROVIDER: S-EPMC3473050 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Seto Jong J Busse Björn B Gupta Himadri S HS Schäfer Cora C Krauss Stefanie S Dunlop John W C JW Masic Admir A Kerschnitzki Michael M Zaslansky Paul P Boesecke Peter P Catalá-Lehnen Philip P Schinke Thorsten T Fratzl Peter P Jahnen-Dechent Willi W
PloS one 20121016 10
The plasma protein fetuin-A/alpha2-HS-glycoprotein (genetic symbol Ahsg) is a systemic inhibitor of extraskeletal mineralization, which is best underscored by the excessive mineral deposition found in various tissues of fetuin-A deficient mice on the calcification-prone genetic background DBA/2. Fetuin-A is known to accumulate in the bone matrix thus an effect of fetuin-A on skeletal mineralization is expected. We examined the bones of fetuin-A deficient mice maintained on a C57BL/6 genetic back ...[more]