Ontology highlight
ABSTRACT:
SUBMITTER: Festuccia N
PROVIDER: S-EPMC3473361 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Festuccia Nicola N Osorno Rodrigo R Halbritter Florian F Karwacki-Neisius Violetta V Navarro Pablo P Colby Douglas D Wong Frederick F Yates Adam A Tomlinson Simon R SR Chambers Ian I
Cell stem cell 20121001 4
Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog expression. However, the mechanisms by which Nanog functions remain unclear, and in particular, direct Nanog target genes are uncharacterized. Here we investigate ESCs expressing different Nanog levels and Nanog(-/-) cells with distinct functionally inducible Nanog proteins to identify Nanog-responsive genes. Surprisingly, these constitute a minor fraction of genes that Nanog binds. Prominent among Nanog-repons ...[more]