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MRNA localization and translational control in Drosophila oogenesis.

ABSTRACT: Localization of an mRNA species to a particular subcellular region can complement translational control mechanisms to produce a restricted spatial distribution of the protein it encodes. mRNA localization has been studied most in asymmetric cells such as budding yeast, early embryos, and neurons, but the process is likely to be more widespread. This article reviews the current state of knowledge about the mechanisms of mRNA localization and its functions in early embryonic development, focusing on Drosophila where the relevant knowledge is most advanced. Links between mRNA localization and translational control mechanisms also are examined.

SUBMITTER: Lasko P

PROVIDER: S-EPMC3475173 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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mRNA localization and translational control in Drosophila oogenesis.

Lasko Paul P

Cold Spring Harbor perspectives in biology 20121001 10

Localization of an mRNA species to a particular subcellular region can complement translational control mechanisms to produce a restricted spatial distribution of the protein it encodes. mRNA localization has been studied most in asymmetric cells such as budding yeast, early embryos, and neurons, but the process is likely to be more widespread. This article reviews the current state of knowledge about the mechanisms of mRNA localization and its functions in early embryonic development, focusing ...[more]

PMID: 22865893

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