Environmental and genetic factors affecting transport of imatinib by OATP1A2.
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ABSTRACT:
SUBMITTER: Eechoute K
PROVIDER: S-EPMC3476732 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Environmental and genetic factors affecting transport of imatinib by OATP1A2.
Eechoute K K Franke R M RM Loos W J WJ Scherkenbach L A LA Boere I I Verweij J J Gurney H H Kim R B RB Tirona R G RG Mathijssen R H J RH Sparreboom A A
Clinical pharmacology and therapeutics 20110420 6
The bioavailability of orally administered imatinib is >90%, although the drug is monocationic under the acidic conditions in the duodenum. In vitro, we found that imatinib is transported by the intestinal uptake carrier organic anion transporting polypeptide (OATP1A2) and that this process is sensitive to pH, rosuvastatin, and genetic variants. However, in a study in patients with cancer, imatinib absorption was not associated with OATP1A2 variants and was unaffected by rosuvastatin. These find ...[more]
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