Ontology highlight
ABSTRACT:
SUBMITTER: Deane KD
PROVIDER: S-EPMC5726551 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Deane Kevin D KD Demoruelle M Kristen MK Kelmenson Lindsay B LB Kuhn Kristine A KA Norris Jill M JM Holers V Michael VM
Best practice & research. Clinical rheumatology 20170201 1
Multiple genetic and environmental factors have been associated with an increased risk for rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female sex, a family history of RA, the genetic factor the "shared epitope," and exposure to tobacco smoke. There is also renewed interest in mucosal inflammation and microbial factors as contributors to the development of RA. However, the identification of a "preclinical" period of RA that can be defined as local or system ...[more]