Ontology highlight
ABSTRACT:
SUBMITTER: Oyoshi MK
PROVIDER: S-EPMC3478399 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Oyoshi Michiko K MK He Rui R Li Yitang Y Mondal Subhanjan S Yoon Juhan J Afshar Roshi R Chen Mei M Lee David M DM Luo Hongbo R HR Luster Andrew D AD Cho John S JS Miller Lloyd S LS Larson Allison A Murphy George F GF Geha Raif S RS
Immunity 20121011 4
Scratching triggers skin flares in atopic dermatitis. We demonstrate that scratching of human skin and tape stripping of mouse skin cause neutrophil influx. In mice, this influx was largely dependent on the generation of leukotriene B4 (LTB4) by neutrophils and their expression of the LTB4 receptor BLT1. Allergic skin inflammation in response to epicutaneous (EC) application of ovalbumin to tape-stripped skin was severely impaired in Ltb4r1(-/-) mice and required expression of BLT1 on both T cel ...[more]