Ontology highlight
ABSTRACT:
SUBMITTER: Kwon SY
PROVIDER: S-EPMC6627931 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kwon Sun-Young SY Kim Jae-Hong JH
International journal of molecular sciences 20190614 12
Mast cells are effector cells in the immune system that play an important role in the allergic airway inflammation. Recently, it was reported that BLT2, a low-affinity leukotriene (LT) B<sub>4</sub> receptor, plays a pivotal role in the pathogenesis of allergic airway inflammation through its action in mast cells. We observed that highly elevated expression levels of BLT2 are critical for the pathogenesis leading to allergic airway inflammation, and that if BLT2 expression is downregulated by si ...[more]