Ontology highlight
ABSTRACT:
SUBMITTER: Reynolds JM
PROVIDER: S-EPMC3478486 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20120928 9
In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-17F, and IL-25 in the host defense against infection and in inflammatory diseases; however, the physiological function of IL-17C remains poorly understood. Using mice deficient in IL-17C, we demonstrate that this cytokine is crucial for the regulation of an acute experimental colitis elicited by dextran sulfate sodium. In this model, mice lacking IL-17C exhibited exacerbated disease that was associated w ...[more]