Dispersion by Pseudomonas aeruginosa requires an unusual posttranslational modification of BdlA.
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ABSTRACT:
SUBMITTER: Petrova OE
PROVIDER: S-EPMC3478618 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Dispersion by Pseudomonas aeruginosa requires an unusual posttranslational modification of BdlA.
Petrova Olga E OE Sauer Karin K
Proceedings of the National Academy of Sciences of the United States of America 20120924 41
Dispersion enables biofilm bacteria to transit from the biofilm to the planktonic growth state and to spawn novel communities in new locales. Although the chemotaxis protein BdlA plays a role in the dispersion of Pseudomonas aeruginosa biofilms in response to environmental cues, little is known about regulation of BdlA activity or how BdlA modulates the dispersion response. Here, we demonstrate that BdlA in its native form is inactive and is activated upon nonprocessive proteolysis at a ClpP-pro ...[more]
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