Ontology highlight
ABSTRACT:
SUBMITTER: Ren Y
PROVIDER: S-EPMC3478735 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Ren Yin Y Hauert Sabine S Lo Justin H JH Bhatia Sangeeta N SN
ACS nano 20120827 10
Tumor-targeted delivery of siRNA remains a major barrier in fully realizing the therapeutic potential of RNA interference. While cell-penetrating peptides (CPP) are promising siRNA carrier candidates, they are universal internalizers that lack cell-type specificity. Herein, we design and screen a library of tandem tumor-targeting and cell-penetrating peptides that condense siRNA into stable nanocomplexes for cell type-specific siRNA delivery. Through physiochemical and biological characterizatio ...[more]