Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides.
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ABSTRACT:
SUBMITTER: Welch JJ
PROVIDER: S-EPMC4904250 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides.
Welch Jade J JJ Swanekamp Ria J RJ King Christiaan C Dean David A DA Nilsson Bradley L BL
ACS medicinal chemistry letters 20160330 6
The promise of oligonucleotide therapeutic agents to perturb expression of disease-related genes remains unrealized, in part due to challenges with functional cellular delivery of these agents. Herein, we describe disulfide-constrained cyclic amphipathic peptides that complex with short-interfering RNA (siRNA) and affect functional cytosolic delivery and knockdown of target gene products in cell culture and in vivo to mouse lung. Reduction of the constraining disulfide bond and subsequent proteo ...[more]
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