Dietary protein affects gene expression and prevents lipid accumulation in the liver in mice.

ABSTRACT:

Background and aims

High protein (HP) diets are suggested to positively modulate obesity and associated increased prevalence of non-alcoholic fatty liver (NAFLD) disease in humans and rodents. The aim of our study was to detect mechanisms by which a HP diet affects hepatic lipid accumulation.

Methods

To investigate the acute and long term effect of high protein ingestion on hepatic lipid accumulation under both low and high fat (HF) conditions, mice were fed combinations of high (35 energy%) or low (10 energy%) fat and high (50 energy%) or normal (15 energy%) protein diets for 1 or 12 weeks. Effects on body composition, liver fat, VLDL production rate and the hepatic transcriptome were investigated.

Results

Mice fed the HP diets displayed a lower body weight, develope

SUBMITTER: Schwarz J 

PROVIDER: S-EPMC3479095 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature