Unknown

Dataset Information

0

Dietary Egg Sphingomyelin Prevents Aortic Root Plaque Accumulation in Apolipoprotein-E Knockout Mice.


ABSTRACT: Western-style diets have been linked with dyslipidemia and inflammation, two well-known risk factors associated with cardiovascular disease (CVD). Dietary sphingomyelin (SM) has been reported to modulate gut microbiota, and lower serum lipids and inflammation in mice on Western-style diets. However, few studies have examined if nutritionally-relevant intake of dietary SM can impact atherosclerosis progression. Thus, the aim of this study was to determine if incorporating 0.1% (w/w) egg SM (ESM) (equivalent to ~750 mg/day in humans) into a high-fat (45% kcal), cholesterol-enriched diet (HFD) could prevent atheroprogression in apoE-/- mice (n = 15/group). We found that mice fed with the ESM-rich diet had significantly lower epididymal fat mass (-46%) and tended to have higher spleen weights (+15%). There were no significant differences in serum lipids between groups. However, ESM-fed mice had significantly lower alanine aminotransferase (ALT) activity. Additionally, ESM-fed mice displayed significantly less aortic root lipid accumulation (-31%) compared to controls. This improvement in atherosclerosis was paired with over a two-fold reduction in circulating serum amyloid A (SAA) in ESM-fed mice. Finally, there was also a modulation of the gut microbiota with ESM supplementation. ESM may have the potential to prevent atherosclerosis, however further research in the clinical setting is warranted.

SUBMITTER: Millar CL 

PROVIDER: S-EPMC6566691 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Dietary Egg Sphingomyelin Prevents Aortic Root Plaque Accumulation in Apolipoprotein-E Knockout Mice.

Millar Courtney L CL   Norris Gregory H GH   Vitols Addison A   Garcia Chelsea C   Seibel Samantha S   Anto Liya L   Blesso Christopher N CN  

Nutrients 20190521 5


Western-style diets have been linked with dyslipidemia and inflammation, two well-known risk factors associated with cardiovascular disease (CVD). Dietary sphingomyelin (SM) has been reported to modulate gut microbiota, and lower serum lipids and inflammation in mice on Western-style diets. However, few studies have examined if nutritionally-relevant intake of dietary SM can impact atherosclerosis progression. Thus, the aim of this study was to determine if incorporating 0.1% (w/w) egg SM (ESM)  ...[more]

Similar Datasets

| S-EPMC2740721 | biostudies-literature
| S-EPMC3299803 | biostudies-literature
| S-EPMC3041652 | biostudies-literature
| S-EPMC8618636 | biostudies-literature
| S-EPMC3869200 | biostudies-literature
| S-EPMC7070176 | biostudies-literature
| S-EPMC5500278 | biostudies-literature
| S-EPMC4239170 | biostudies-literature
| S-EPMC6815845 | biostudies-literature
| S-EPMC2771227 | biostudies-literature