Ontology highlight
ABSTRACT:
SUBMITTER: Moindrot B
PROVIDER: S-EPMC3479194 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Moindrot Benoit B Audit Benjamin B Klous Petra P Baker Antoine A Thermes Claude C de Laat Wouter W Bouvet Philippe P Mongelard Fabien F Arneodo Alain A
Nucleic acids research 20120808 19
Although chromatin folding is known to be of functional importance to control the gene expression program, less is known regarding its interplay with DNA replication. Here, using Circular Chromatin Conformation Capture combined with high-throughput sequencing, we identified megabase-sized self-interacting domains in the nucleus of a human lymphoblastoid cell line, as well as in cycling and resting peripheral blood mononuclear cells (PBMC). Strikingly, the boundaries of those domains coincide wit ...[more]