Ontology highlight
ABSTRACT:
SUBMITTER: Rowley MJ
PROVIDER: S-EPMC5591081 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rowley M Jordan MJ Nichols Michael H MH Lyu Xiaowen X Ando-Kuri Masami M Rivera I Sarahi M ISM Hermetz Karen K Wang Ping P Ruan Yijun Y Corces Victor G VG
Molecular cell 20170817 5
Topologically associating domains (TADs), CTCF loop domains, and A/B compartments have been identified as important structural and functional components of 3D chromatin organization, yet the relationship between these features is not well understood. Using high-resolution Hi-C and HiChIP, we show that Drosophila chromatin is organized into domains we term compartmental domains that correspond precisely with A/B compartments at high resolution. We find that transcriptional state is a major predic ...[more]