Ontology highlight
ABSTRACT:
SUBMITTER: Blau L
PROVIDER: S-EPMC3479486 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Blau Lior L Knirsh Revital R Ben-Dror Iris I Oren Sivan S Kuphal Silke S Hau Peter P Proescholdt Martin M Bosserhoff Anja-Katrin AK Vardimon Lily L
Proceedings of the National Academy of Sciences of the United States of America 20121001 42
Although the protooncogene c-Jun plays a critical role in cell proliferation, cell death, and malignant transformation, DNA microarray screens have identified only a few human cancer types with aberrant expression of c-Jun. Here, we show that c-Jun accumulation is robustly elevated in human glioblastoma and that this increase contributes to the malignant properties of the cells. Most importantly, the increase in c-Jun protein accumulation occurs with no corresponding increase in c-Jun mRNA or th ...[more]