Ontology highlight
ABSTRACT:
SUBMITTER: Onoguchi M
PROVIDER: S-EPMC3479495 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Onoguchi Masahiro M Hirabayashi Yusuke Y Koseki Haruhiko H Gotoh Yukiko Y
Proceedings of the National Academy of Sciences of the United States of America 20121001 42
The proneural basic helix-loop-helix (bHLH) transcription factor neurogenin1 (Neurog1) plays a pivotal role in neuronal differentiation during mammalian development. The spatiotemporal control of the Neurog1 gene expression is mediated by several specific enhancer elements, although how these elements regulate the Neurog1 locus has remained largely unclear. Recently it has been shown that a large number of enhancer elements are transcribed, but the regulation and function of the resulting transc ...[more]