Integrative functional genomics identifies RINT1 as a novel GBM oncogene.
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ABSTRACT:
SUBMITTER: Quayle SN
PROVIDER: S-EPMC3480269 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Integrative functional genomics identifies RINT1 as a novel GBM oncogene.
Quayle Steven N SN Chheda Milan G MG Shukla Sachet A SA Wiedemeyer Ruprecht R Tamayo Pablo P Dewan Robert W RW Zhuang Li L Huang-Hobbs Emmet E Haidar Sam S Xiao Yonghong Y Ligon Keith L KL Hahn William C WC Chin Lynda L
Neuro-oncology 20121016 11
Large-scale cancer genomics efforts are identifying hundreds of somatic genomic alterations in glioblastoma (GBM). Distinguishing between active driver and neutral passenger alterations requires functional assessment of each gene; therefore, integrating biological weight of evidence with statistical significance for each genomic alteration will enable better prioritization for downstream studies. Here, we demonstrate the feasibility and potential of in vitro functional genomic screens to rapidly ...[more]
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