Ontology highlight
ABSTRACT:
SUBMITTER: Boehringer J
PROVIDER: S-EPMC3481250 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
The Biochemical journal 20121101 1
The ubiquitin-proteasome system targets selected proteins for degradation by the 26S proteasome. Rpn12 is an essential component of the 19S regulatory particle and plays a role in recruiting the extrinsic ubiquitin receptor Rpn10. In the present paper we report the crystal structure of Rpn12, a proteasomal PCI-domain-containing protein. The structure helps to define a core structural motif for the PCI domain and identifies potential sites through which Rpn12 might form protein-protein interactio ...[more]