Leptin signaling in adipose tissue: role in lipid accumulation and weight gain.

ABSTRACT:

Rationale

The link between obesity, hyperleptinemia, and development of cardiovascular disease is not completely understood. Increases in leptin have been shown to impair leptin signaling via caveolin-1-dependent mechanisms. However, the role of hyperleptinemia versus impaired leptin signaling in adipose tissue is not known.

Objective

To determine the presence and significance of leptin-dependent increases in adipose tissue caveolin-1 expression in humans.

Methods and results

We designed a longitudinal study to investigate the effects of increases in leptin on adipose tissue caveolin-1 expression during weight gain in humans. Ten volunteers underwent 8 weeks of overfeeding, during which they gained an average weight of 4.1±1.4 kg, with leptin increases from 7±3.8 to 1

SUBMITTER: Singh P 

PROVIDER: S-EPMC3482005 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature