Ontology highlight
ABSTRACT:
SUBMITTER: Tam AB
PROVIDER: S-EPMC3482226 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Tam Arvin B AB Mercado Ellen L EL Hoffmann Alexander A Niwa Maho M
PloS one 20121026 10
NF-κB, a transcription factor, becomes activated during the Unfolded Protein Response (UPR), an endoplasmic reticulum (ER) stress response pathway. NF-κB is normally held inactive by its inhibitor, IκBα. Multiple cellular pathways activate IKK (IκBα Kinase) which phosphorylate IκBα leading to its degradation and NF-κB activation. Here, we find that IKK is required for maximum activation of NF-κB in response to ER stress. However, unlike canonical NFκB activation, IKK activity does not increase d ...[more]