Ontology highlight
ABSTRACT:
SUBMITTER: Foglia F
PROVIDER: S-EPMC3482691 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Foglia Fabrizia F Lawrence M Jayne MJ Demeė Bruno B Fragneto Giovanna G Barlow David D
Scientific reports 20121029
Over the last 50 years or so, amphotericin has been widely employed in treating life-threatening systemic fungal infections. Its usefulness in the clinic, however, has always been circumscribed by its dose-limiting side-effects, and it is also now compromised by an increasing incidence of pathogen resistance. Combating these problems through development of new anti-fungal agents requires detailed knowledge of the drug's molecular mechanism, but unfortunately this is far from clear. Neutron diffr ...[more]