Ontology highlight
ABSTRACT:
SUBMITTER: Leng S
PROVIDER: S-EPMC3483793 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Leng Shuguang S Do Kieu K Yingling Christin M CM Picchi Maria A MA Wolf Holly J HJ Kennedy Timothy C TC Feser William J WJ Baron Anna E AE Franklin Wilbur A WA Brock Malcolm V MV Herman James G JG Baylin Stephen B SB Byers Tim T Stidley Christine A CA Belinsky Steven A SA
Clinical cancer research : an official journal of the American Association for Cancer Research 20120417 12
<h4>Purpose</h4>To evaluate the methylation state of 31 genes in sputum as biomarkers in an expanded nested, case-control study from the Colorado cohort, and to assess the replication of results from the most promising genes in an independent case-control study of asymptomatic patients with stage I lung cancer from New Mexico.<h4>Experimental design</h4>Cases and controls from Colorado and New Mexico were interrogated for methylation of up to 31 genes using nested, methylation-specific PCR. Indi ...[more]