Ontology highlight
ABSTRACT:
SUBMITTER: Do H
PROVIDER: S-EPMC3935198 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Do Hongdo H Wong Nicholas C NC Murone Carmel C John Thomas T Solomon Benjamin B Mitchell Paul L PL Dobrovic Alexander A
Scientific reports 20140226
DNA repair genes that have been inactivated by promoter methylation offer potential therapeutic targets either by targeting the specific repair deficiency, or by synthetic lethal approaches. This study evaluated promoter methylation status for eight selected DNA repair genes (ATM, BRCA1, ERCC1, MGMT, MLH1, NEIL1, RAD23B and XPC) in 56 non-small cell lung cancer (NSCLC) tumours and 11 lung cell lines using the methylation-sensitive high resolution melting (MS-HRM) methodology. Frequent methylatio ...[more]