Ontology highlight
ABSTRACT:
SUBMITTER: Baxi SM
PROVIDER: S-EPMC3485233 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20121031 10
Binding of IGF to IGF-IR activates PI3K to generate PIP3 which in turn recruits and activates proteins that contain a pleckstrin homology (PH) domain, including AKT and PDK1. PDK1 is highly expressed in breast tumor samples and breast cancer cell lines. Here we demonstrate that targeting PDK1 with the potent and selective PDK1 inhibitor PF-5177624 in the IGF-PI3K pathway blocks breast cancer cell proliferation and transformation. Breast cancer cell lines MCF7 and T47D, representing the luminal E ...[more]