Ontology highlight
ABSTRACT:
SUBMITTER: Darieva Z
PROVIDER: S-EPMC3486177 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Darieva Zoulfia Z Han Namshik N Warwood Stacey S Doris Kathryn S KS Morgan Brian A BA Sharrocks Andrew D AD
Molecular and cellular biology 20120910 22
The control of the cell cycle in eukaryotes is exerted in part by the coordinated action of a series of transcription factor complexes. This is exemplified by the Mcm1p-Fkh2p-Ndd1p complex in Saccharomyces cerevisiae, which controls the cyclical expression of the CLB2 cluster of genes at the G(2)/M phase transition. The activity of this complex is positively controlled by cyclin-dependent kinase (CDK) and polo kinases. Here, we demonstrate that the protein kinase Pkc1p works in the opposite mann ...[more]