Ontology highlight
ABSTRACT:
SUBMITTER: Khalil H
PROVIDER: S-EPMC3486191 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20120904 22
The ability to generate appropriate defense responses is crucial for the survival of an organism exposed to pathogenesis-inducing insults. However, the mechanisms that allow tissues and organs to cope with such stresses are poorly understood. Here we show that caspase-3-knockout mice or caspase inhibitor-treated mice were defective in activating the antiapoptotic Akt kinase in response to various chemical and environmental stresses causing sunburns, cardiomyopathy, or colitis. Defective Akt acti ...[more]