Proteomics

Dataset Information

0

Caspase-2 protects against ferroptotic cell death


ABSTRACT: To identify proteins that interact with caspase-2 that could potentially explain its ability to regulate ferroptosis, we performed an unbiased BioID proteomics screen.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: Laura Dagley  

LAB HEAD: A/Prof Nicholas Clemons

PROVIDER: PXD041339 | Pride | 2024-03-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
DIANN.zip Other
P4097_01_1_1_6898.d.zip Other
P4097_02_1_1_6906.d.zip Other
P4097_03_1_1_6890.d.zip Other
P4097_04_1_1_6888.d.zip Other
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Publications


Caspase-2, one of the most evolutionarily conserved members of the caspase family, is an important regulator of the cellular response to oxidative stress. Given that ferroptosis is suppressed by antioxidant defense pathways, such as that involving selenoenzyme glutathione peroxidase 4 (GPX4), we hypothesized that caspase-2 may play a role in regulating ferroptosis. This study provides the first demonstration of an important and unprecedented function of caspase-2 in protecting cancer cells from  ...[more]

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