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Complete genome sequence of Le Blanc virus, a third Caenorhabditis nematode-infecting virus.


ABSTRACT: Orsay virus and Santeuil virus, the first known viruses capable of naturally infecting the nematodes Caenorhabditis elegans and Caenorhabditis briggsae, respectively, were recently identified by high-throughput sequencing of wild Caenorhabditis strains. By similar analysis of another wild C. briggsae isolate, we have now discovered and sequenced the complete genome of a third novel virus, Le Blanc virus, that is distantly related to Orsay and Santeuil viruses. All three viruses are positive-sense RNA viruses with bipartite genomes that are most closely related to nodaviruses. Identification of a third virus capable of infecting Caenorhabditis nematodes enables comparative analysis of this clade of viruses and strengthens this model for investigating virus-host interactions.

SUBMITTER: Franz CJ 

PROVIDER: S-EPMC3486331 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Complete genome sequence of Le Blanc virus, a third Caenorhabditis nematode-infecting virus.

Franz Carl J CJ   Zhao Guoyan G   Félix Marie-Anne MA   Wang David D  

Journal of virology 20121101 21


Orsay virus and Santeuil virus, the first known viruses capable of naturally infecting the nematodes Caenorhabditis elegans and Caenorhabditis briggsae, respectively, were recently identified by high-throughput sequencing of wild Caenorhabditis strains. By similar analysis of another wild C. briggsae isolate, we have now discovered and sequenced the complete genome of a third novel virus, Le Blanc virus, that is distantly related to Orsay and Santeuil viruses. All three viruses are positive-sens  ...[more]

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