Ontology highlight
ABSTRACT:
SUBMITTER: Rand AC
PROVIDER: S-EPMC3488302 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Rand Arthur C AC Leung Siegfried S F SS Eng Heather H Rotter Charles J CJ Sharma Raman R Kalgutkar Amit S AS Zhang Yizhong Y Varma Manthena V MV Farley Kathleen A KA Khunte Bhagyashree B Limberakis Chris C Price David A DA Liras Spiros S Mathiowetz Alan M AM Jacobson Matthew P MP Lokey R Scott RS
MedChemComm 20121001 10
A series of cyclic peptides were designed and prepared to investigate the physicochemical properties that affect oral bioavailabilty of this chemotype in rats. In particular, the ionization state of the peptide was examined by the incorporation of naturally occurring amino acid residues that are charged in differing regions of the gut. In addition, data was generated in a variety of in vitro assays and the usefulness of this data in predicting the subsequent oral bioavailability observed in the ...[more]