Ontology highlight
ABSTRACT:
SUBMITTER: Appelbaum JS
PROVIDER: S-EPMC3488872 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Appelbaum Jacob S JS LaRochelle Jonathan R JR Smith Betsy A BA Balkin Daniel M DM Holub Justin M JM Schepartz Alanna A
Chemistry & biology 20120701 7
Proteins represent an expanding class of therapeutics, but their actions are limited primarily to extracellular targets because most peptidic molecules fail to enter cells. Here we identified two small proteins, miniature protein 5.3 and zinc finger module ZF5.3, that enter cells to reach the cytosol through rapid internalization and escape from Rab5+ endosomes. The trafficking pathway mapped for these molecules differs from that of Tat and Arg(8), which require transport beyond Rab5+ endosomes ...[more]