Ontology highlight
ABSTRACT:
SUBMITTER: Carrasquillo MM
PROVIDER: S-EPMC3489170 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Carrasquillo Minerva M MM Belbin Olivia O Belbin Olivia O Hunter Talisha A TA Ma Li L Bisceglio Gina D GD Zou Fanggeng F Crook Julia E JE Pankratz V Shane VS Sando Sigrid B SB Aasly Jan O JO Barcikowska Maria M Wszolek Zbigniew K ZK Dickson Dennis W DW Graff-Radford Neill R NR Petersen Ronald C RC Morgan Kevin K Younkin Steven G SG
Journal of Alzheimer's disease : JAD 20110101 4
The most recent late-onset Alzheimer's disease (LOAD) genome-wide association study revealed genome-wide significant association of two new loci: rs744373 near BIN1 (p = 1.6 × 10-11) and rs597668 near EXOC3L2/BLOC1S3/MARK4 (p = 6.5 × 10-9). We have genotyped these variants in a large (3,287 LOAD, 4,396 controls), independent dataset comprising eleven case-control series from the USA and Europe. We performed meta-analyses of the association of these variants with LOAD and also tested for associat ...[more]