Ontology highlight
ABSTRACT:
SUBMITTER: Costello DA
PROVIDER: S-EPMC3489278 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Costello Deirdre A DA Lee Donald W DW Drewes Jennifer J Vasquez Kevin A KA Kisler Kassandra K Wiesner Ulrich U Pollack Lois L Whittaker Gary R GR Daniel Susan S
Analytical chemistry 20121001 20
We report a method for studying membrane fusion, focusing on influenza virus fusion to lipid bilayers, which provides high temporal resolution through the rapid and coordinated initiation of individual virus fusion events. Each fusion event proceeds through a series of steps, much like multistep chemical reaction. Fusion is initiated by a rapid decrease in pH that accompanies the "uncaging" of an effector molecule from o-nitrobenzaldehyde, a photoisomerizable compound that releases a proton to t ...[more]