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Gold-Triggered Uncaging Chemistry in Living Systems.

ABSTRACT: Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

SUBMITTER: Perez-Lopez AM

PROVIDER: S-EPMC5655737 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Gold-Triggered Uncaging Chemistry in Living Systems.

Pérez-López Ana M AM Rubio-Ruiz Belén B Sebastián Víctor V Hamilton Lloyd L Adam Catherine C Bray Thomas L TL Irusta Silvia S Brennan Paul M PM Lloyd-Jones Guy C GC Sieger Dirk D Santamaría Jesús J Unciti-Broceta Asier A

Angewandte Chemie (International ed. in English) 20170809 41

Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the ...[more]

PMID: 28699691

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