Conditional deletion of TrkC does not modify limbic epileptogenesis.
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ABSTRACT:
SUBMITTER: Soren Leonard A
PROVIDER: S-EPMC3489989 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
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Conditional deletion of TrkC does not modify limbic epileptogenesis.
Soren Leonard A A Puranam Ram S RS Helgager Jeffrey J Liu Gumei G McNamara James O JO
Epilepsy research 20120912 1-2
The neurotrophin receptor, tropomyosin-related kinase B (TrkB), is required for epileptogenesis in the kindling model. The role of a closely related neurotrophin receptor, TrkC, in limbic epileptogenesis is unknown. We examined limbic epileptogenesis in the kindling model in TrkC conditional null mice, using a strategy that previously established a critical role of TrkB. Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wi ...[more]
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