Ontology highlight
ABSTRACT:
SUBMITTER: Pascal LE
PROVIDER: S-EPMC5679084 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Pascal Laura E LE Masoodi Khalid Z KZ Liu June J Qiu Xiaonan X Song Qiong Q Wang Yujuan Y Zang Yachen Y Yang Tiejun T Wang Yao Y Rigatti Lora H LH Chandran Uma U Colli Leandro M LM Vencio Ricardo Z N RZN Lu Yi Y Zhang Jian J Wang Zhou Z
The Journal of endocrinology 20171101 2
Elongation factor, RNA polymerase II, 2 (ELL2) is an RNA Pol II elongation factor with functional properties similar to ELL that can interact with the prostate tumor suppressor EAF2. In the prostate, <i>ELL2</i> is an androgen response gene that is upregulated in benign prostatic hyperplasia (BPH). We recently showed that ELL2 loss could enhance prostate cancer cell proliferation and migration, and that <i>ELL2</i> gene expression was downregulated in high Gleason score prostate cancer specimens ...[more]