Ontology highlight
ABSTRACT:
SUBMITTER: Miki M
PROVIDER: S-EPMC3490151 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Miki Motohiro M Katayama Kazuhiko K
Frontiers in microbiology 20121106
Norwalk virus (NoV) is responsible for most outbreaks of non-bacterial gastroenteritis. NoV is genetically diverse and show antigenically variable. Recently, we produced a monoclonal antibody called 5B-18 that reacts broadly with NoV genogroup II (GII). We suspected the 5B-18 binds to a conformational epitope on 3D structure of virion. X-ray crystallography showed us that 5B-18 binds to NoV at the P domain, which protrudes from the capsid surface of the virion. However, there seems to be no spac ...[more]