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IFN-inducible GTPases in host cell defense.

ABSTRACT: From plants to humans, the ability to control infection at the level of an individual cell-a process termed cell-autonomous immunity-equates firmly with survival of the species. Recent work has begun to unravel this programmed cell-intrinsic response and the central roles played by IFN-inducible GTPases in defending the mammalian cell's interior against a diverse group of invading pathogens. These immune GTPases regulate vesicular traffic and protein complex assembly to stimulate oxidative, autophagic, membranolytic, and inflammasome-related antimicrobial activities within the cytosol, as well as on pathogen-containing vacuoles. Moreover, human genome-wide association studies and disease-related transcriptional profiling have linked mutations in the Immunity-Related GTPase M (IRGM) locus and altered expression of guanylate binding proteins (GBPs) with tuberculosis susceptibility and Crohn's colitis.

SUBMITTER: Kim BH

PROVIDER: S-EPMC3490204 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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IFN-inducible GTPases in host cell defense.

Kim Bae-Hoon BH Shenoy Avinash R AR Kumar Pradeep P Bradfield Clinton J CJ MacMicking John D JD

Cell host & microbe 20121001 4

From plants to humans, the ability to control infection at the level of an individual cell-a process termed cell-autonomous immunity-equates firmly with survival of the species. Recent work has begun to unravel this programmed cell-intrinsic response and the central roles played by IFN-inducible GTPases in defending the mammalian cell's interior against a diverse group of invading pathogens. These immune GTPases regulate vesicular traffic and protein complex assembly to stimulate oxidative, auto ...[more]

PMID: 23084913

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